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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10599 | BRAF inhibitor | Raf | |
BRAF inhibitor is an inhibitor of B-Raf. | |||
T8745 | PROTAC BRAF-V600E degrader-1 | Compound 23 | Raf |
PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF. | |||
T1845 | B-Raf IN 1 | Raf | |
B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor. | |||
T9638 | CCT241161 | Raf | |
CCT241161 is an orally active pan-RAF inhibitor, with IC50 values of 3, 6, 10, 15, and 30 nM for LCK, CRAF, SRC, V600E-BRAF, and BRAF, respectively. It displays significant activity against BRAF and NRAS mutant melanomas... | |||
T6971 | Ro 5126766 | CH5126766,Avutometinib,VS-6766,RO5126766 | Raf , MEK |
RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1. | |||
T72070 | B-Raf IN 14 | Bradykinin Receptor | |
B-Raf IN 14 is a BRAF inhibitor. | |||
T5172 | AZ304 | c-Fms , Raf , p38 MAPK , Autophagy | |
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM). | |||
T3579 | PLX8394 | Raf | |
PLX8394 is an orally active inhibitor of serine/threonine-protein kinase B-Raf (BRAF) protein. PLX8394 can selectively bind to and inhibit the activity of both wild-type and mutated forms of BRAF, then inhibit the prolif... | |||
T6487 | Encorafenib | LGX818 | Raf |
Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity. | |||
T40284 | B-Raf IN 2 | Raf | |
B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research. | |||
T2070 | Agerafenib | RXDX-105,CEP 32496,CEP-32496,CEP32496 | Raf , c-RET , Bcr-Abl , PDGFR , Src , c-Kit |
Agerafenib (CEP32496) is a highly potent inhibitor of BRAF. | |||
T79830 | B-Raf IN 16 | Raf | |
B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research. | |||
T78183 | B-Raf IN 15 | Raf | |
B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used in the study of melanoma and cancer, and can be optimized for use as a more effective BRA F inhibitor. | |||
T6949 | PLX7904 | PB04 | Raf |
PLX7904 (PB04), also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutan... | |||
TQ0048 | BI-882370 | Raf | |
BI-882370 is a specific RAF kinase inhibitor. BI-882370 inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases (IC50s: 0.4, 0.8 and 0.6 nM). BI-882370 also inhibits SRC family kinases. | |||
T9693 | TBAP-001 | Raf | |
TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay. | |||
T2382 | Vemurafenib | RO5185426,RG7204,PLX4032 | Raf , MAPK , ACK , Src , Autophagy |
Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently. Vemurafenib exhibits antitumor activity and is used for the treatment of BRAF V600E mutation-positive... | |||
T6318 | AZ 628 | Apoptosis , Raf | |
AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. | |||
T63333 | Uplarafenib | B-Raf IN 10 | Raf |
Uplarafenib (B-Raf IN 10) is a potent BRAF inhibitor with an IC50 in the range of 50-100 nM.B-Raf IN 10 has antitumor activity that may affect cell proliferation and differentiation did not, and can be used to study soli... | |||
T3711 | RAF709 | Raf | |
RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively. |